Luria said of Zazetsky that he had entirely lost his capacity to play games but that his "vivid imagination" was unimpaired. Zazetsky and Dr P. lived in worlds which were mirror images of each other. But the saddest difference between them was that Zazetsky, as Luria said, "fought to regain his lost faculties with the indomitable tenacity of the damned," whereas Dr P. was not fighting, did not know what was lost, did not indeed know that anything was lost. But who was more tragic, or who was more damned - the man who knew it, or the man who did not?
— The Man Who Mistook His Wife for a Hat
by Oliver Sacks