typeracer

An interesting biochemical feature of natriuretic peptide signal peptide fragments in the human circulation is that they are all differentially modified at their amino terminus residue. These modifications may be related to reactive species formed during oxidative stress processes in acute MI, such as glyoxal and methylglyoxal, resulting in adduct formation such as formyl, methyl, and carboxyethyl groups on Leu, Ala, and Thr residues.